Bioorganic and Medicinal Chemistry Letters p. 4812 - 4819 (2015)
Update date:2022-08-05
Topics:
Egbertson, Melissa
McGaughey, Georgia B.
Pitzenberger, Steven M.
Stauffer, Shaun R.
Coburn, Craig A.
Stachel, Shawn J.
Yang, Wenjin
Barrow, James C.
Neilson, Lou Anne
McWherter, Melody
Perlow, Debra
Fahr, Bruce
Munshi, Sanjeev
Allison, Timothy J.
Holloway, Katharine
Selnick, Harold G.
Yang, Zhiqiang
Swestock, John
Simon, Adam J.
Sankaranarayanan, Sethu
Colussi, Dennis
Tugusheva, Katherine
Lai, Ming-Tain
Pietrak, Beth
Haugabook, Shari
Jin, Lixia
Chen
Holahan, Marie
Stranieri-Michener, Maria
Cook, Jacquelynn J.
Vacca, Joseph
Graham, Samuel L.
The IC50 of a beta-secretase (BACE-1) lead compound was improved ~200-fold from 11 μM to 55 nM through the addition of a single methyl group. Computational chemistry, small molecule NMR, and protein crystallography capabilities were used to com
View MoreChengdu Chengnuo New-Tech Co., Ltd
Contact:0086-028-85749078
Address:4 Jiuyang road,Jiulong industrial port,Chengdu, China
Contact:86-512-69362780,69362785
Address:No.69 Weixin Road,Weiting Town,Suzhou Industrial Park
Shantou Baokang Pharmaceutical Co., Ltd.
Contact:+86-754-88873487
Address:5/F B Block Huangshan Bldg Huangshan Rd Shantou
Hangzhou innopharma technology Co,.Ltd.(expird)
Contact:+86-13388601988
Address:Room845,lixin building, moganshan road, hangzhou, china
MS( MAOSHENG )Chemical CO.,LTD
Contact:+86-519-82726678.82726378
Address:TAOXI INDUSTRY ZONE JINTAN
Doi:10.1021/ol902023g
(2009)Doi:10.1021/jo00276a043
(1989)Doi:10.1207/S15327841Mpee0401_3
(1935)Doi:10.1039/b907577a
(2009)Doi:10.1055/s-0029-1217811
(2009)Doi:10.1039/b902916h
(2009)