Enantio- and stereoselective route to the phoslactomycin family of antibiotics: Formal synthesis of (+)-fostriecin and (+)-phoslactomycin B

Article abstract of DOI:10.1039/b912267b

A general methodology applicable for the synthesis of the phoslactomycin family of antibiotics, potent and selective protein phosphatase inhibitors, has been developed starting from a β-isocupreidine-catalyzed asymmetric Baylis-Hillman reaction of 3-(4-me