Synthesis of New Aromatic Retinoid Analogues by Low-Valent Titanium Induced Reductive Elimination

Article abstract of DOI:10.1021/jo00272a032

The low-valent titanium reductive elimination reaction, already applied to the stereospecific synthesis of vitamin A and 13-cis-retinol, was used to prepare several retinoic acid analogues in the all-trans configuration or in the 13-cis configuration.This highly stereospecific trans-diene formation allowed an improved synthesis of the title compounds without any purification of the intermediates before the final stage.