Journal of Medicinal Chemistry p. 1208 - 1213 (1989)
Update date:2022-08-04
Topics:
Rizzi, James P.
Schnur, Rodney C.
Hutson, Nancy J.
Kraus, Kenneth G.
Kelbaugh, Paul R.
Sorbinil (1), a spirocyclic hydantoin, is a potent inhibitor of the enzyme aldose reductase.Simulation of the rigid spirocyclic ring orientation found in sorbinil was achieved with nonspirocyclic 5-<5'-chloro-2'-(alkylsulfonyl)phenyl>hydantoins and 5-<5'-
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