Rotationally Restricted Mimics of Rigid Molecules: Nonspirocyclic Hydantion Aldose Reductase Inhibitors

Article abstract of DOI:10.1021/jm00126a011

Sorbinil (1), a spirocyclic hydantoin, is a potent inhibitor of the enzyme aldose reductase.Simulation of the rigid spirocyclic ring orientation found in sorbinil was achieved with nonspirocyclic 5-<5'-chloro-2'-(alkylsulfonyl)phenyl>hydantoins and 5-<5'-