Synthesis and Biological Evaluation of S-Adenosyl-1,12-diamino-3-thio-9-azadodecane, a Multisubstrate Adduct Inhibitor of Spermine Synthase

DOI: 10.1021/jm00126a026

Source and publish data:

Journal of Medicinal Chemistry p. 1300 - 1307 (1989)

Update date:2022-08-05

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Authors:

Woster, Patrick M.

Black, Alison Y.

Duff, Keith J.

Coward, James K.

Pegg, Anthony E.

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Article abstract of DOI:10.1021/jm00126a026

As part of a continuing search for specific inhibitors of the enzymes involved in polyamine biosynthesis, we have designed and synthesized a multisubstrate adduct inhibitor, S-adenosyl-1,12-diamino-3-thio-9-azadodecane (AdoDATAD), in which critical portio

Full text of DOI:10.1021/jm00126a026

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