1,4-DIOXENE IN ORGANIC CHEMISTRY. PART VII REGIOSPECIFIC OXIDATIVE CLEAVAGE OF 1,4-DIOXENYL CARBINOLS WITH PYRIDINIUM CHLOROCHROMATE. A NEW METHOD FOR THE PREPARATION OF α-HYDROXY ACIDS AND α-KETO ACIDS.

Article abstract of DOI:10.1016/S0040-4039(00)82320-5

The allylic alcohols 1 obtained from lithiated 1,4-dioxene and ketones or aldehydes undergo regiospecifically oxidative cleavage with pyridinium chlorochromate at the dioxene double bond to give, after saponification, α-hydroxy acids.Extension of this rea