OPTICALLY ACTIVE α-ALKYLSUCCINATES FROM THE STEREOSELECTIVE ALKYLATION OF CHIRAL IMIDE ENOLATES.

DOI: 10.1016/S0040-4039(00)82319-9

Source and publish data:

Tetrahedron Letters p. 6257 - 6260 (1988)

Update date:2022-08-03

Topics:

Authors:

Fadel, Antonine

Salauen, Jacques

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Article abstract of DOI:10.1016/S0040-4039(00)82319-9

The chiral oxazolidinones 1 and 2 were alkylated by methyl bromoacetate, then subsequent removal of the chiral auxiliary provided readily with high stereoselectivity the α-alkylated succinates 7 and 8.Acyloin condensation and bromination gave the optically active α-t-butylcyclobutanedione 10.

Full text of DOI:10.1016/S0040-4039(00)82319-9

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