PEPTIDIC TRIFLUOROMETHYL ALCOHOLS AND KETONES A GENERAL SYNTHESIS AND APPLICATION AS RENIN INHIBITORS

DOI: 10.1016/S0040-4039(00)80575-4

Source and publish data:

Tetrahedron Letters p. 4665 - 4668 (1988)

Update date:2022-08-04

Topics:

Authors:

Patel, Dinesh V.

Rielly-Gauvin, Katherine

Ryono, Denis E.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)80575-4

Preparation of the tripeptidic trifluoromethyl alcohol 9 and ketone 10 and their evaluation as renin inhibitors is described.The key step is the Curtius rearrangement of the beta-silyloxy acid 6 prepared via condensation of trifluoroacetaldehyde with the

Full text of DOI:10.1016/S0040-4039(00)80575-4

Products guided by the article

Product name:[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-propyl]-carbamic acid benzyl ester

Cas No:120586-88-1

R&D Labs maybe for 120586-88-1

Beijing ZhongDaXinHe Chemical Product Co.,Ltd(expird)

Contact:010-52876516

Address:tongzhoubeiyuan
Hangzhou Neway Chemicals Co., Ltd.

Contact:+86-571-85095566

Address:Room 803, Qinglian Bldg, No 139 Qingchun Road, Hangzhou, Zhejiang China
Taizhou YOJOY Chemical Co., Ltd.

Contact:13857143241

Address:Yangfu Industrial Park, Xianju, Zhejiang, P. R. China
Shijiazhuang Sdyano Fine Chemical Co., Ltd

Contact:+86-311-89830448

Address:NO.48 Ta Nan Road,Yuhua District,Shijiazhuang,Hebei,China
Shanghai Xinda Pharmaceuticals Co., Ltd.

Contact:86-21-33692333-8008

Address:999 Linxian Road, Jinshan Industrial Park, Shanghai, China

Relevant to this article

Exploration and determination of the redox properties of the pseudopterosin class of marine natural products

Doi:10.1016/j.tet.2009.09.021
(2009)
Partial ring-opening and rearrangement reactions of P,C-cages to yield unusual phosphinous acids stabilized by pentacarbonyltungsten

Doi:10.1021/om9009334
(2010)
A practical synthesis of renin inhibitor MK-1597 (ACT-178882) via catalytic enantioselective hydrogenation and epimerization of piperidine intermediate

Doi:10.1021/jo102070e
(2011)
Phosphine catalyzed [3+2] cyclization/Michael addition of allenoate with CS₂to form 2-thineyl vinyl sulfide

Doi:10.1039/d0cc05070a
(2020)
Gold-catalyzed cyclization of 1-alkynyl cyclopropyl tert-butyl carbonate to construct multifunctionalized vinyl cyclopropane derivatives

Doi:10.1016/j.tet.2009.10.087
(2010)
Asymmetric synthesis of 4-ethoxy-1-p-tolylsulfonyl-3,6-dioxabicyclo[3.1.0]hexan-2-ones

Doi:10.1016/j.tet.2009.10.106
(2010)

Article Doi