PEPTIDIC TRIFLUOROMETHYL ALCOHOLS AND KETONES A GENERAL SYNTHESIS AND APPLICATION AS RENIN INHIBITORS

DOI: 10.1016/S0040-4039(00)80575-4

Source and publish data:

Tetrahedron Letters p. 4665 - 4668 (1988)

Update date:2022-08-04

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Authors:

Patel, Dinesh V.

Rielly-Gauvin, Katherine

Ryono, Denis E.

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Article abstract of DOI:10.1016/S0040-4039(00)80575-4

Preparation of the tripeptidic trifluoromethyl alcohol 9 and ketone 10 and their evaluation as renin inhibitors is described.The key step is the Curtius rearrangement of the beta-silyloxy acid 6 prepared via condensation of trifluoroacetaldehyde with the

Full text of DOI:10.1016/S0040-4039(00)80575-4

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