SYNTHESIS OF A PROSTAGLANDIN ENDOPEROXIDE MODEL COMPOUND AND ITS REACTION WITH ELECTRON TRANSFER REAGENTS

Article abstract of DOI:10.1016/S0040-4020(01)86176-7

5-Exo-phenyl-2,3-dioxabicyclo<2.2.1>heptane (4c) was synthesized as a model compound of prostaglandin endoperoxide (PGH) to mimic the bioconversion of PGH into thromboxane (TX).The reaction of (4c) with various electron transfer reagents was investigated.With the aid of a catalytic amount of ferrous ion, (4c) was successfully converted into the thromboxane B (TXB) skeleton.