
Tetrahedron p. 4737 - 4746 (1988)
Update date:2022-09-26
Topics: Synthesis Prostaglandin
Takahashi, Kimio
Kishi, Morio
5-Exo-phenyl-2,3-dioxabicyclo<2.2.1>heptane (4c) was synthesized as a model compound of prostaglandin endoperoxide (PGH) to mimic the bioconversion of PGH into thromboxane (TX).The reaction of (4c) with various electron transfer reagents was investigated.With the aid of a catalytic amount of ferrous ion, (4c) was successfully converted into the thromboxane B (TXB) skeleton.
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