Synthesis of the Novel ?-(Benzyloxymethyl)-Protected Histidine Analogue of Statine. Inhibition of Penicillopepsin by Pepstatin-Derived Peptides Containing Different Statine Side-Chain Derivatives

DOI: 10.1021/jm00127a028

Source and publish data:

Journal of Medicinal Chemistry p. 1571 - 1576 (1989)

Update date:2022-07-30

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Authors:

Maibaum, Juergen

Rich, Daniel H.

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Article abstract of DOI:10.1021/jm00127a028

The synthesis of aspartic proteinase inhibitors derived from a new histidine side-chain analogue of statine (Sta), (3S,4S)-4-amino-3-hydroxy-5-(imidazol-4-yl)pentanoic acid (HiSta, 20), is reported.Boc-HiSta(BOM)-OMe (7) was prepared in 16percent overall

Full text of DOI:10.1021/jm00127a028

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