Journal of medicinal chemistry p. 1335 - 1340 (1989)
Update date:2022-08-02
Topics: Synthesis Inhibitors Kinetic studies Derivatization N1-alkyl-substituted derivatives Chlorpropamide Aldehyde dehydrogenase Enzyme assay
Nagasawa
Elberling
DeMaster
Shirota
On the basis of an earlier observation that the N1-ethyl derivative of the hypoglycemic agent chlorpropamide (CP) inhibited aldehyde dehydrogenase (AlDH) in rats without producing hypoglycemia, we undertook a structure-activity study to assess the effect
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