Application of Isocyanides as Amide Surrogates in the Synthesis of Diverse Isoindolin-1-one Derivatives by a Palladium-Catalyzed Tandem Carboxamidation/Hydroamidation Reaction

DOI: 10.1002/ejoc.201600999

Source and publish data:

European Journal of Organic Chemistry p. 5579 - 5587 (2016)

Update date:2022-08-05

Topics:

Authors:

Pathare, Ramdas S

Sharma, Shivani

Elagandhula, Sathish

Saini, Vaishali

Sawant, Devesh M

Yadav, Monika

Sharon, Ashoke

Khan, Shahnawaz

Pardasani, Ram T

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Article abstract of DOI:10.1002/ejoc.201600999

The rapid synthesis of the isoindolinone skeleton has been accomplished by a palladium-catalyzed one-pot tandem process, which consists of an isocyanide insertion/hydration (carboxamidation) and 5-exo-dig cycloisomerization (hydroamidation) reaction seque

Full text of DOI:10.1002/ejoc.201600999

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