Tetrahedron Letters p. 543 - 546 (1989)
Update date:2022-08-04
Topics:
Grandas, Ana
Marshall, William S.
Nielsen, John
Caruthers, Marvin H.
Deoxydicytidine phosphoramidite, 4-chlorobenzylmercaptan and tetrazole reacted to form dinucleoside thiophosphite.Oxidation with sulfur yields phosphorodithioates which used to synthesize pentadecadeoxyoligonucleotides containing nuclease resistant phosphorodithioate internucleotide linkages.
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