SYNTHESIS OF DEOXYCYTIDINE OLIGOMERS CONTAINING PHOSPHORODITHIOATE LINKAGES

DOI: 10.1016/S0040-4039(00)95248-1

Source and publish data:

Tetrahedron Letters p. 543 - 546 (1989)

Update date:2022-08-04

Topics:

Authors:

Grandas, Ana

Marshall, William S.

Nielsen, John

Caruthers, Marvin H.

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Article abstract of DOI:10.1016/S0040-4039(00)95248-1

Deoxydicytidine phosphoramidite, 4-chlorobenzylmercaptan and tetrazole reacted to form dinucleoside thiophosphite.Oxidation with sulfur yields phosphorodithioates which used to synthesize pentadecadeoxyoligonucleotides containing nuclease resistant phosphorodithioate internucleotide linkages.

Full text of DOI:10.1016/S0040-4039(00)95248-1

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