Activation of 6-Endo over 5-Exo Hydroxy Epoxide Openings. Stereoselective and Ring Selective Synthesis of Tetrahydrofuran and Tetrahydropyran Systems

DOI: 10.1021/ja00196a043

Source and publish data:

Journal of the American Chemical Society p. 5330 - 5334 (1989)

Update date:2022-08-04

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Authors:

Nicolaou, K. C.

Prasad, C. V. C.

Somers, P. K.

Hwang, C.-K.

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Article abstract of DOI:10.1021/ja00196a043

A well-defined and predictable route to tetrahydrofurans and tetrahydropyrans is described.The method relies on stereo- and regioselective opening of hydroxy epoxides by acid catalysis.The presence of a saturated chain at the remote (from the hydroxy grou

Full text of DOI:10.1021/ja00196a043

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