QUANTITATIVE SEPARATION AND ANALYSIS OF DIASTEREOMERS OF L-METHIONINE-S,R-SULFOXIMINE VIA CYCLIC N-BLOCKED DERIVATIVES

Article abstract of DOI:10.1016/S0040-4039(00)81684-6

The diastereomers of L-methionine-S,R-sulfoximine, blocked at α-N with phthaloyl, then cyclized with Ac2O to form 3,4,5,6-tetrahydro-1-methyl-3-oxo-4-(N-phthalimido)-1,2-thiazine-1-oxide, could be easily separated by fractional crystallization or HPLC, whereas the parent compounds were very difficult to separate.