Palladium Mediated Formation of Δ1- and Δ2-Carbapenems by Cyclofunctionalization of 4-Allenylazetidinones and 4-(2-Propynyl)azetidinones.

Article abstract of DOI:10.1016/S0040-4039(00)80468-2

A palladium catalyzed cyclofunctionalization of a 4-allenylazetidinone to Δ¹-carbapenems and of 4-(2-propynyl)-azetidinones to Δ²-carbapenems is described.A palladium(2+) catalyst induces nucleophilic closure of the azetidinone nitro