Med Chem Res (2011) 20:453–460
459
˘
Das¸-Evcimen N, Bozdag-Du¨ndar O, Sarıkaya M, Ertan R (2008)
In vitro aldose reductase inhibitory activity of some flavonyl-2.4-
thiazolidinediones. JEIMC 23:297–301
h has shown the best inhibitory activity among the other
DHA derivatives.
The results of the biological evaluation allowed us to get
insight into initial structural features critical for AR inhi-
bition in this series. Thus, based on these findings further
modifications are envisaged. Due to the shortage of drugs
currently available for the treatment of diabetic complica-
tions, search for new ARIs endowed with more favorable
biological properties is still a major pharmaceutical
challenge.
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