Journal of the Chemical Society. Perkin transactions I p. 221 - 224 (1989)
Update date:2022-08-04
Topics:
Atfah, Adnan
Hill, John
The Beirut reaction of 2,1,3-benzoxadiazole 1-oxide and ethyl 2,4-dioxo-4-phenylbutryate in ethanol, or acetonitrile, catalysed by triethylamine gave first ethyl 3-benzoylquinoxaline-2-carboxylate 1,4-dioxide and then, in a slower reaction, 2-benzoylquinoxaline 1,4-dioxide. The latter was isolated in two distinct stable crystalline forms. The effects of changing the proportions of the reactants, the tertiary alkylamine used, and the temperature have been studied. Both above-mentioned 1,4-dioxides were reduced to the corresponding quinoxalines. Ethyl 3-benzoylquinoxaline-2-carboxylate 1,4-dioxide decomposed slowly to several products in ethanol in the presence of triethylamine or diethylamine and was converted by ethanolic potassium hydroxide into the potassium salt of quinoxaline-2-carboxylic acid 1,4-dioxide.
View MoreZhengzhou Institute of Chiral Pharmer Research Co., Ltd.
Contact:86-371-55219111
Address:15 Floor, 2 Building, Central China Technovalley, Zhongyuan West Road
SHAANXI FUJIE PHARMACEUTICAL CO.,LTD
website:http://www.fujiepharm.com
Contact:+86-29-63650906
Address:Yuanqu Yi Road, Qinghe Food Industrial Park, Sanyuan County, Shaanxi Province, China
Ji'nan Orgachem Pharmaceutical Co.,Ltd
Contact:+86-531-82687810
Address:Jinan
Contact:86 513 85512619
Address:Rm.1306, Building A, Wenfeng Mansion,168 Gongnong Road, Nantong Jiangsu China
Contact:+86-371-55981030
Address:Room 1571, Macalline Soho, No.1, Shangdu Road, Zhengzhou, Henan
Doi:10.1016/j.apcata.2013.07.001
(2013)Doi:10.1080/00397911.2013.800552
(2014)Doi:10.1021/om900764q
(2010)Doi:10.1080/00397910902985531
(2010)Doi:10.1002/jhet.301
(2010)Doi:10.1055/s-0029-1217048
(2010)
