Orally Active Aldose Reductase Inhibitors Derived from Bioisosteric Substitutions on Tolrestat

DOI: 10.1021/jm00131a012

Source and publish data:

Journal of Medicinal Chemistry p. 2493 - 2502 (1989)

Update date:2022-08-03

Topics:

Authors:

Wrobel, Jay

Millen, Jane

Sredy, Janet

Dietrich, Arlene

Kelly, Joseph M.

et al. et al.

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Article abstract of DOI:10.1021/jm00131a012

A series of aldose reductase inhibitors was prepared in which structural modifications were made to three positions of the potent, orally active inhibitor tolrestat (1), namely, the 6-methoxy substituent, thioamide sulfur, and the N-methyl moiety.These co

Full text of DOI:10.1021/jm00131a012

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