Synthesis p. 493 - 497 (2010)
Update date:2022-08-05
Topics:
Mityuk, Andrey P.
Denisenko, Aleksandr V.
Dacenko, Oleksandr P.
Grygorenko, Oleksandr O.
Mykhailiuk, Pavel K.
Volochnyuk, Dmitriy M.
Shishkin, Oleg V.
Tolmachev, Andrey A.
Chlorotrimethylsilane-promoted double Mannich annulation of ketones using N,N-bis(methoxymethyl)benzylamine has been explored. It has been shown that the structure of the substrate drastically influenced the outcome of the reaction. The method allows azabicyclo[n.3.1]alkane derivatives (n=2-5) to be obtained in good yields. Georg Thieme Verlag Stuttgart New York.
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Doi:10.1016/j.tet.2010.01.111
(2010)Doi:10.1021/jo1000516
(2010)Doi:10.3987/COM-11-12351
(2011)Doi:10.1016/j.tet.2010.02.026
(2010)Doi:10.1016/j.bmc.2010.01.023
(2010)Doi:10.1021/ic901925w
(2010)
