Palladium(II)-Assisted Carboacylation of Enamides To Produce Functionalized β-Amino Acids. Synthesis of Relays to (+/-)-Thienamycin

DOI: 10.1021/jo00280a036

Source and publish data:

Journal of Organic Chemistry p. 4649 - 4653 (1989)

Update date:2022-08-03

Topics:

Authors:

Wieber, Gary M.

Hegedus, Louis S.

Akermark, Bjoern

Michalson, Erik T.

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Article abstract of DOI:10.1021/jo00280a036

Alkylation of benzyl vinylcarbamate with sodium benzyl acetoacetate in the presence of palladium(II) chloride, followed by carbonylation (CO/MeOH), produced a highly functionalized β-amido ester that was converted, using conventional organic synthetic methodology, into a relay to (+/-)-thienamycin.

Full text of DOI:10.1021/jo00280a036

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