Palladium(II)-Assisted Carboacylation of Enamides To Produce Functionalized β-Amino Acids. Synthesis of Relays to (+/-)-Thienamycin

Article abstract of DOI:10.1021/jo00280a036

Alkylation of benzyl vinylcarbamate with sodium benzyl acetoacetate in the presence of palladium(II) chloride, followed by carbonylation (CO/MeOH), produced a highly functionalized β-amido ester that was converted, using conventional organic synthetic methodology, into a relay to (+/-)-thienamycin.