PROSTAGLANDINS: TOTAL SYNTHESIS OF PGD2 "via" 1,3 CYCLOPENTANEDIONE

DOI: 10.1016/S0040-4020(01)96540-8

Source and publish data:

Tetrahedron p. 1385 - 1392 (1985)

Update date:2022-08-03

Topics:

Authors:

Cainelli, Gianfranco

Giacomini, Daria

Panunzio, Mauro

Martelli, Giorgio

Spunta, Giuseppe

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Article abstract of DOI:10.1016/S0040-4020(01)96540-8

A practical total synthesis of PGD₂ starting from an acyclic precursor is reported.A novel efficient inversion of stereochemistry at C₉ tosylate group "via" a SN₂ displacement by tetrabutylammonium nitrate is described.

Full text of DOI:10.1016/S0040-4020(01)96540-8

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