Synthesis and bradykinin inhibitory activity of novel non-peptide compounds, and evaluation of in vivo analgesic activity

DOI: 10.1016/j.bmc.2010.01.050

Source and publish data:

Bioorganic and Medicinal Chemistry p. 2327 - 2336 (2010)

Update date:2022-08-02

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Authors:

Kam, Yoo Lim

Rhee, Hee-Kyung

Kim, Hwa-Jung

Back, Seung Keun

Na, Heung Sik

Choo, Hea-Young Park

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Article abstract of DOI:10.1016/j.bmc.2010.01.050

A series of novel non-peptide diamide compounds was synthesized and evaluated as antibradykinin agents by utilizing guinea-pig ileum smooth muscle. Among the final compounds, (Z)-4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-4-oxo-N-(4-phenylbutan-2-yl)

Full text of DOI:10.1016/j.bmc.2010.01.050

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