Phenanthrylalkanoic acids, III: Syntheses and biological activities of 4-phenanthryl derivatives.

DOI: 10.1002/ardp.19893220508

Source and publish data:

Archiv der Pharmazie p. 281 - 284 (1989)

Update date:2022-08-02

Topics:

Authors:

Eirin Eirin

Fernandez

Gomez Gomez

Lopez Lopez

Santos Santos

Calleja Calleja

Cano Cano

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Article abstract of DOI:10.1002/ardp.19893220508

Reformatsky reactions between 2,3-dihydro-4(1H)-phenanthrenone (5) and ethyl alpha-bromoacetate or propanoate yield several unsaturated esters which, upon aromatization followed by saponification, lead to the 4-phenanthrylacetic (1) and 2-(4-phenanthryl)propanoic (2) acids. The analgesic and anti-inflammatory properties of 1 and 2 were measured and compared with those of Fenbufen.

Full text of DOI:10.1002/ardp.19893220508

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