Archiv der Pharmazie p. 281 - 284 (1989)
Update date:2022-08-02
Topics:
Eirin
Fernandez
Gomez
Lopez
Santos
Calleja
Cano
Reformatsky reactions between 2,3-dihydro-4(1H)-phenanthrenone (5) and ethyl alpha-bromoacetate or propanoate yield several unsaturated esters which, upon aromatization followed by saponification, lead to the 4-phenanthrylacetic (1) and 2-(4-phenanthryl)propanoic (2) acids. The analgesic and anti-inflammatory properties of 1 and 2 were measured and compared with those of Fenbufen.
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