Synthesis and Evaluation of N,N-Di-n-propyltetrahydrobenzindol-7-amine and Related Congeners as Dopaminergic Agonists

DOI: 10.1021/jm00129a017

Source and publish data:

Journal of Medicinal Chemistry p. 2128 - 2134 (1989)

Update date:2022-08-04

Topics: Synthesis Evaluation Lipophilicity Selectivity Nuclear magnetic resonance (NMR) spectroscopy Mass spectrometry (MS) Congeners HPLC (high-performance liquid chromatography) Structure-Activity Relationship (SAR) Dopamine D2 Receptor Dose-Response Curve Metabolic Stability In vitro assay In vivo assay Receptor binding assay IC50 (Half-Maximal Inhibitory Concentration) EC50 (Half-Maximal Effective Concentration)

Authors:

Nichols, David E.

Cassady, John M.

Persons, Paul E.

Yeung, Ming C.

Clemens, James A.

Smalstig, E. Barry

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Article abstract of DOI:10.1021/jm00129a017

An evaluation of 6-<2-(di-n-propylamino)ethyl>indole (4), its rigid analogue N,N-di-n-propyl-5,6,7,8-tetrahydrobenzindol-7-amine (5), and some related congeners, for ability to suppress serum prolactin in reserpinized rats, revealed modest biological a

Full text of DOI:10.1021/jm00129a017

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