Letters in Organic Chemistry p. 423 - 426 (2011)
Update date:2022-07-31
Topics:
Wang, Tao
Tian, Rui
Xiao, Bin
Shen, Yi
Zhou, Hui
Li, Qingeng
A novel protocol for the synthesis of Ibutilide Fumarate (raceme) was achieved from 2-pyrrolidinone with an overall yield of 15%. The core structure was constructed in one step based on Friedel-Crafts acylation with an acyl chloride containing an amino hydrochloride.
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