Application of the anionic oxy-cope rearrangement to stereocontrolled synthesis of the A/B subunit of cytoxic 8,9-seco-ent-kaurenes

Article abstract of DOI:10.1055/s-1992-34185

Methodology is described for expedient synthesis of the A/B framework of 8,9-seco-ent-kaurenes and for introduction of the 5-methylene-2-cyclopentenone moiety. In the first part of the study, a sequence of only six steps is necessary to convert 2-(hydroxy