CYCLOPEPTIDE ALKALOID MODEL STUDIES. A TWO-STEP CONVERSION OF 5-AMINOISOXAZOLES TO AMINO ACID BIS-AMIDES

Article abstract of DOI:10.1016/S0040-4039(00)82266-2

Thermolyses of substituted 5-aminoisoxazoles, readily available from common starting materials, lead to azirines in good yields.Subsequent hydration affords bis-amide derivatives of amino acids.