Comprehensive Synthetic Route to Eight Diastereomeric Podophyllum Lignans

DOI: 10.1021/jo00279a011

Source and publish data:

Journal of Organic Chemistry p. 4280 - 4290 (1989)

Update date:2022-07-31

Topics:

Authors:

Forsey, Steven P.

Rajapaksa, Dayananda

Taylor, Nicholas J.

Rodrigo, Russell

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Article abstract of DOI:10.1021/jo00279a011

An oxabicyclo compound, 9, prepared in 47percent yield through an isobenzofuran intermediate was converted with excellent regio- and stereocontrol to eight (+/-)-lignan lactones of the podophyllotoxin series.One of the eight, epiisopicropodophyllin, 36, t

Full text of DOI:10.1021/jo00279a011

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