Advanced Synthesis and Catalysis p. 839 - 842 (2010)
Update date:2022-08-03
Topics:
Sun, Jianwei
Keller, Valerie A.
Meyer, S. Todd
Kozmin, Sergey A.
We describe the development of a silvercatalyzed carbonyl olefination employing electronrich siloxyalkynes. This process constitutes an efficient synthesis of trisubstituted unsaturated esters, and represents an alternative to the widely utilized Horner-Wadsworth-Emmons reaction. Excellent diastereoselectivities are observed for a range of aldehydes using either 1-siloxy-l-propyne or 1-siloxy1-hexyne. This mild catalytic process also enables chemoselective olefination of aldehydes in the presence of either ester or ketone functionality. Furthermore, since no by-products are generated, this catalytic process is perfectly suited for development of sequential reactions that can be carried out in a single flask.
View MoreContact:86-511-85210668 0511-85210668, 85210818, 85210898
Address:Yihai Garden E-902,NO.99 Daxi RD., Zhenjiang Jiiangsu ,China
Shanghai Coupling Pharmaceutical R&D Co., Ltd.(expird)
Contact:+86 021 50106671
Address:403 Room No.4 Buiding, No. 526 Ruiqing Road, Shanghai Zhangjiang Hi-Tech Park
He Bei Shun Er Chemical Co., LTD.
Contact:86-0311-86996932/86860168
Address:No 18,North street
Contact:+86-371-86058576
Address:NO.32, Jingsan Road, Zhengzhou, China
QINGDAO DEVELOP chemistry Co.,Limited
Contact:+86-532-85807910
Address:98#Nanjing Road, Qingdao, China 266071
Doi:10.1016/j.bmcl.2010.02.071
(2010)Doi:10.3987/COM-11-12248
(2011)Doi:10.1080/00304941003676895
(2010)Doi:10.1016/j.jorganchem.2010.02.022
(2010)Doi:10.1002/ejic.201402286
(2014)Doi:10.1021/jo1004235
(2010)