A-ring modifications on the triazafluorenone core structure and their mGluR1 antagonist properties

DOI: 10.1016/j.bmcl.2010.03.004

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2474 - 2477 (2010)

Update date:2022-08-05

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Authors:

Sasikumar

Qiang, Li

Burnett, Duane A.

Greenlee, William J.

Li, Cheng

Grilli, Mariagrazia

Bertorelli, Rosalia

Lozza, Gianluca

Reggiani, Angelo

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Article abstract of DOI:10.1016/j.bmcl.2010.03.004

A-ring modifications on the triazafluorenone core structure were investigated. Five membered heterocycles such as pyrazoles and isothiazoles are not tolerated. It has been found that the pyrimidine nucleus was very well tolerated on the left hand side. Am

Full text of DOI:10.1016/j.bmcl.2010.03.004

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