Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development

DOI: 10.1021/jm400487c

Source and publish data:

Journal of Medicinal Chemistry p. 5979 - 5983 (2013)

Update date:2022-08-03

Topics:

Authors:

Ding, Qingjie

Zhang, Zhuming

Liu, Jin-Jun

Jiang, Nan

Zhang, Jing

Ross, Tina M.

Chu, Xin-Jie

Bartkovitz, David

Podlaski, Frank

Janson, Cheryl

Tovar, Christian

Filipovic, Zoran M.

Higgins, Brian

Glenn, Kelli

Packman, Kathryn

Vassilev, Lyubomir T.

Graves, Bradford

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Article abstract of DOI:10.1021/jm400487c

Restoration of p53 activity by inhibition of the p53-MDM2 interaction has been considered an attractive approach for cancer treatment. However, the hydrophobic protein-protein interaction surface represents a significant challenge for the development of s

Full text of DOI:10.1021/jm400487c

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