Journal of Organic Chemistry p. 4795 - 4800 (1989)
Update date:2022-08-04
Topics:
Barnett, Charles J.
Copley-Merriman, Catherine R.
Maki, James
A convenient synthesis of the novel phenylpiperidine analgesic agent picenadol, (+/-)-1, via tetrahydropyridine 2 is described.Tetrahydropyridine 7, prepared from 6 via metalation (n-butyllithium) and alkylation with 1-bromopropane, could not be directly
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Doi:10.1021/ol1009416
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