Chemistry Letters p. 1410 - 1411 (2004)
Update date:2022-09-26
Topics:
Mukaiyama, Teruaki
Tozawa, Takashi
Fujisawa, Hidehiko
Michael reaction between silyl enolates and α,β-unsaturated carbonyl compounds by using a catalytic amount of Lewis base such as lithium alkoxide in DMF proceeds smoothly to afford the corresponding Michael-adducts in good yields with moderate to high diastereoselectivities. This reaction can be reasonably explained by considering an alkoxide anion-initiated autocatalytic process.
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