Structural Studies on Bioactive Compounds. 8. Synthesis, Crystal Structure, and Biological Properties of a New Series of 2,4-Diamino-5-aryl-6-ethylpyrimidine Dihydrofolate Reductase Inhibitors with in Vivo Activity against a Methotrexate-Resistant Tumor C

DOI: 10.1021/jm00131a009

Source and publish data:

Journal of Medicinal Chemistry p. 2468 - 2474 (1989)

Update date:2022-08-05

Topics:

Authors:

Griffin, Roger J.

Meek, Michelle A.

Schwalbe, Carl H.

Stevens, Malcolm F. G.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00131a009

A series of 2,4-diamino-5-aryl-6-ethylpyrimidines embracing basic substituents in the 5-aryl ring was synthesized and evaluated for inhibitory activity against rat liver dihydrofolate reductase (DHFR).Maximal enzyme inhibition was observed for compounds b

Full text of DOI:10.1021/jm00131a009

Products guided by the article

Product name:NSC 372939

Cas No:123240-27-7

R&D Labs maybe for 123240-27-7

Shanghai Harvest Chemical Ind. Co., Ltd.

Contact:021-51385350

Address:ROOM 806-807, AI LI CHEN BUILDING, No.333 JINGXIANG ROAD, PUDONG DISTRICT, 201206, SHANGHAI
Richest Group Ltd.

Contact:+86 21 5017 5386

Address:No 999,Jiangyue Rd, Minhang Dist ,201114,Shanghai ,China
Sichuan Highlight Fine Chemicals Co., Ltd.

Contact:+86-28-8525 1605

Address:A5-102 Airport base,388 West Airport Huang He Zhong Lu,2 Section
Chemieliva Pharmaceutical Co., Ltd.

website:http://www.chemieliva.com

Contact:+86-23-67770219

Address:99 Longhua Road, Yubei District, 401147, Chongqing, China Email: sales@chemieliva.com Tel:0086-23-67770219 Fax: 0086-23-67770220 Attn: Andy Huang
Chengdu Yunyi International Trade Co., Ltd

Contact:

Address:china

Relevant to this article

A New Synthesis of 3,4-Diaryl-5-oxo-4,5-dihydroisoxazoles and Their Transformation to 5-isoxazoles and 5-(2-Aminoethylthio)isoxazoles

Doi:10.1055/s-1989-27221
(1989)
A convenient synthetic approach to alpha-amino-beta-lactam synthesis promoted by phenyl dichlorophosphate reagent

Doi:10.1016/S0040-4039(01)91200-6
(1984)
An open-and-shut strategy: Preparation of benzo-fused indanes by ring-opening of a vinylogous acyl triflate and metal-catalyzed Asao-Yamamoto benzannulation

Doi:10.1016/j.tet.2010.03.014
(2010)
Nickel complexes with bis(8-quinolyl)silyl ligands. An unusual Ni ₃Si₂ cluster containing six-coordinate silicon

Doi:10.1021/om1004622
(2010)
Development of tryptase inhibitors derived from thalidomide

Doi:10.1016/j.bmc.2010.05.037
(2010)
Fulvadienes derived from fluorenes and their oxidation to spirodiazatetracenes

Doi:10.1055/s-0029-1218773
(2010)

Article Doi