Structural Studies on Bioactive Compounds. 8. Synthesis, Crystal Structure, and Biological Properties of a New Series of 2,4-Diamino-5-aryl-6-ethylpyrimidine Dihydrofolate Reductase Inhibitors with in Vivo Activity against a Methotrexate-Resistant Tumor C

DOI: 10.1021/jm00131a009

Source and publish data:

Journal of Medicinal Chemistry p. 2468 - 2474 (1989)

Update date:2022-08-05

Topics:

Authors:

Griffin, Roger J.

Meek, Michelle A.

Schwalbe, Carl H.

Stevens, Malcolm F. G.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00131a009

A series of 2,4-diamino-5-aryl-6-ethylpyrimidines embracing basic substituents in the 5-aryl ring was synthesized and evaluated for inhibitory activity against rat liver dihydrofolate reductase (DHFR).Maximal enzyme inhibition was observed for compounds b

Full text of DOI:10.1021/jm00131a009

Products guided by the article

Product name:NSC 372939

Cas No:123240-27-7

R&D Labs maybe for 123240-27-7

Yuan Shi(SuQian)Biotechnology Co.,Ltd

website:http://www.yuanshibio.com

Contact:+86-527-84226672

Address:jiangsu suqian
Shanghai Mintchem Development ., Ltd

Contact:0086 21 5190 8570

Address:R602,4#,89Nong, Mudan Road Pudong Shanghai China
Lianyungang Ningkang Chemical Co., Ltd

Contact:.+86-518-88588008

Address:http://www.chemnk.com
Zhejiang Hoshine Silicon Industry Co., Ltd.

Contact:86-573-89179966

Address:Zhapu Town, Pinghu City, Zhejiang, China
Changzhou Litong Chemical Co., Ltd.

website:http://www.litonchem.com/

Contact:+86-519-86301238

Address:Laoba Rd, Hutang town Changzhou Jiangsu

Relevant to this article

A New Synthesis of 3,4-Diaryl-5-oxo-4,5-dihydroisoxazoles and Their Transformation to 5-isoxazoles and 5-(2-Aminoethylthio)isoxazoles

Doi:10.1055/s-1989-27221
(1989)
A convenient synthetic approach to alpha-amino-beta-lactam synthesis promoted by phenyl dichlorophosphate reagent

Doi:10.1016/S0040-4039(01)91200-6
(1984)
An open-and-shut strategy: Preparation of benzo-fused indanes by ring-opening of a vinylogous acyl triflate and metal-catalyzed Asao-Yamamoto benzannulation

Doi:10.1016/j.tet.2010.03.014
(2010)
Nickel complexes with bis(8-quinolyl)silyl ligands. An unusual Ni ₃Si₂ cluster containing six-coordinate silicon

Doi:10.1021/om1004622
(2010)
Development of tryptase inhibitors derived from thalidomide

Doi:10.1016/j.bmc.2010.05.037
(2010)
Fulvadienes derived from fluorenes and their oxidation to spirodiazatetracenes

Doi:10.1055/s-0029-1218773
(2010)

Article Doi