Journal of Medicinal Chemistry p. 2468 - 2474 (1989)
Update date:2022-08-05
Topics:
Griffin, Roger J.
Meek, Michelle A.
Schwalbe, Carl H.
Stevens, Malcolm F. G.
A series of 2,4-diamino-5-aryl-6-ethylpyrimidines embracing basic substituents in the 5-aryl ring was synthesized and evaluated for inhibitory activity against rat liver dihydrofolate reductase (DHFR).Maximal enzyme inhibition was observed for compounds b
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Doi:10.1055/s-1989-27221
(1989)Doi:10.1016/S0040-4039(01)91200-6
(1984)Doi:10.1016/j.tet.2010.03.014
(2010)Doi:10.1021/om1004622
(2010)Doi:10.1016/j.bmc.2010.05.037
(2010)Doi:10.1055/s-0029-1218773
(2010)
