Structural Studies on Bioactive Compounds. 8. Synthesis, Crystal Structure, and Biological Properties of a New Series of 2,4-Diamino-5-aryl-6-ethylpyrimidine Dihydrofolate Reductase Inhibitors with in Vivo Activity against a Methotrexate-Resistant Tumor C

DOI: 10.1021/jm00131a009

Source and publish data:

Journal of Medicinal Chemistry p. 2468 - 2474 (1989)

Update date:2022-08-05

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Authors:

Griffin, Roger J.

Meek, Michelle A.

Schwalbe, Carl H.

Stevens, Malcolm F. G.

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Article abstract of DOI:10.1021/jm00131a009

A series of 2,4-diamino-5-aryl-6-ethylpyrimidines embracing basic substituents in the 5-aryl ring was synthesized and evaluated for inhibitory activity against rat liver dihydrofolate reductase (DHFR).Maximal enzyme inhibition was observed for compounds b

Full text of DOI:10.1021/jm00131a009

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