Journal of Medicinal Chemistry p. 1998 - 2003 (1991)
Update date:2022-09-26
Topics:
Lavielle
Hautefaye
Schaeffer
Boutin
Cudennec
Pierre
A series of new amino phosphonic acid derivatives of vinblastine (1, VLB) has been synthesized and tested in vitro and in vivo for antitumor activity. The compounds were obtained from O4-deacetyl-VLB azide (5). All of the new products studied w
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