New α-amino phosphonic acid derivatives of vinblastine: Chemistry and antitumor activity

DOI: 10.1021/jm00111a012

Source and publish data:

Journal of Medicinal Chemistry p. 1998 - 2003 (1991)

Update date:2022-09-26

Topics:

Authors:

Lavielle

Hautefaye

Schaeffer

Boutin Boutin

Cudennec

Pierre Pierre

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Article abstract of DOI:10.1021/jm00111a012

A series of new amino phosphonic acid derivatives of vinblastine (1, VLB) has been synthesized and tested in vitro and in vivo for antitumor activity. The compounds were obtained from O⁴-deacetyl-VLB azide (5). All of the new products studied w

Full text of DOI:10.1021/jm00111a012

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