CONVENIENT ROUTES TO ALKYL-SUBSTITUTED POLYAMINES

DOI: 10.1016/S0040-4039(00)82421-1

Source and publish data:

Tetrahedron Letters p. 6651 - 6654 (1988)

Update date:2022-08-05

Topics:

Authors:

Golding, Bernard T.

O"Sullivan, Mary C.

Smith, Lewis L.

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Article abstract of DOI:10.1016/S0040-4039(00)82421-1

Alkyl-substituted polyamines, valuable for biological studies, can be prepared from N-phenylmethoxycarbonyl-1,4-diaminobutane (1b) and N-phenylmethoxycarbonyl-4-azidobutanamine (4a) by utilising the following reactions: (i) reduction of the phenylmethoxycarbonyl group to methyl by borane and (ii) combination of the Staudinger and aza-Wittig reactions .

Full text of DOI:10.1016/S0040-4039(00)82421-1

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Product name:N-(benzyloxycarbonyl)-4-(dimethylamino)butylamine

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