Journal of Organic Chemistry p. 5548 - 5550 (1989)
Update date:2022-08-05
Topics:
Mootoo, David R.
Fraser-Reid, Bert
A tripyranoside 2 has been prepared whose 10-carbon chain is folded so as to afford mutual internal protection of acetal groups.A cis-anti-trans-stereosurface is thereby provided which allows for stereocontrolled development of eight of the nine contiguous asymmetric centers of the ansa chain of streptovaricin A.The "upper" acetal ring is cleaved, and the ninth stereocenter is installed in intermediate 10 by using acyclic stereocontrol principles.The remaining acetal is then opened, and the functional groups exposed thereby are manipulated.All nine stereocenters are created with high stereoselectivity, and the termini of the resulting array, 14b, are suitably differentiated for eventual coupling with the pseudoaromatic residue.
View MoreHebei Lead Bio-Chemicals Co., Ltd.
website:http://www.ldbiochem.com
Contact:+86-311-87826503
Address:481, Heping West Road, Shijiazhuang,China
Contact:86-21-50966856
Address:Building 5,300 Chuanzhan Road,Pudong New District,Shanghai
Jiangxi Huashi Pharmaceutical Co., Ltd
Contact:+86-795-4509628
Address:Ningbo Ave., Fengtian Industrial Park, Fengxin Country, Jiangxi, China.
HANGZHOU ZHONGCHANG SCIENTIFIC CO.,LTD
Contact:+86-571-88932183
Address:Hangzhou
Binzhou Holly Pharmaceutical Co.,Ltd.
Contact:74517
Address:No.15 Dapu Road,Huangpu District Shanghai,P.R.China
Doi:10.1039/c39890001041
(1989)Doi:10.1002/ejic.200900975
(2010)Doi:10.1002/jhet.360
(2010)Doi:10.1016/j.tetlet.2010.04.080
(2010)Doi:10.1002/chem.201200480
(2012)Doi:10.1021/acs.orglett.1c01184
(2021)