Synthesis of chiral 2-oxo- and 2-thio-1,3,2-oxazaphospho-lidines via the asymmetric cyclization of l-serinoates with (thio)phosphoryl dichlorides

Article abstract of DOI:10.1080/00397910008086986

In this paper is described the asymmetric cyclization of L-serine derivatives with phosphoro(no-)dichloridates or their thio-analogues, and investigated the asymmetric induction effect of chiral carbon centre on the forming chiral phosphorus centre. Some cyclization products have been separated as a pure diastereomer and their configuration is preliminarily discussed.

Full text of DOI:10.1080/00397910008086986

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Synthetic Communications: An
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Synthesis of Chiral 2-
OXO- and 2-THIO-1,3,2-
Oxazaphospholidines via
the Asymmetric Cyclization
of L-Serinoates with
(Thio)Phosphoryl Dichlorides
Zheng-Jie He a , Wen-Bin Chen a , Zheng-Hong Zhou
a & Chu-Chi Tang a
a The State Key Laboratory of Elemento-Organic
Chemistry, Institute of Elemento-Organic Chemistry,
Nankai University , Tianjin, 300071, P. R. China
Published online: 04 Dec 2007.
To cite this article: Zheng-Jie He , Wen-Bin Chen , Zheng-Hong Zhou & Chu-Chi Tang
(2000) Synthesis of Chiral 2-OXO- and 2-THIO-1,3,2-Oxazaphospholidines via the
Asymmetric Cyclization of L-Serinoates with (Thio)Phosphoryl Dichlorides, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 30:18, 3473-3479, DOI: 10.1080/00397910008086986
To link to this article: http://dx.doi.org/10.1080/00397910008086986
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