Journal of the Chemical Society. Chemical communications p. 1018 - 1019 (1990)
Update date:2022-08-04
Topics:
Watson, Keith G.
Fung, Yik M.
Gredley, Matthew
Bird, Graham J.
Jackson, W. Roy
Gountzos, Helen
Matthews, Barry R.
Efficient enantioselective syntheses of the important cardiac drug (+)-cis-(2S,3S)-diltiazem from (E)-methyl 4-methoxyphenylpropenoate via either the (2R,3S)- or (2S,3R)-enantiomers of threo-methyl 3-(4-methoxyphenyl)-2,3- dihydroxypropanoate are described.
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