Asymmetric syntheses of (+)-diltiazem hydrochloride

DOI: 10.1039/C39900001018

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1018 - 1019 (1990)

Update date:2022-08-04

Topics:

Authors:

Watson, Keith G.

Fung, Yik M.

Gredley, Matthew

Bird, Graham J.

Jackson, W. Roy

Gountzos, Helen

Matthews, Barry R.

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Article abstract of DOI:10.1039/C39900001018

Efficient enantioselective syntheses of the important cardiac drug (+)-cis-(2S,3S)-diltiazem from (E)-methyl 4-methoxyphenylpropenoate via either the (2R,3S)- or (2S,3R)-enantiomers of threo-methyl 3-(4-methoxyphenyl)-2,3- dihydroxypropanoate are described.

Full text of DOI:10.1039/C39900001018

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Product name:(2S,3R)-2-Acetoxy-3-chloro-3-(4-methoxy-phenyl)-propionic acid methyl ester

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