Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 1. Lactones of Pyridine- and Pyrimidine-Substituted 3,5-Dihydroxy-6-heptenoic (-heptanoic) Acids

DOI: 10.1021/jm00163a010

Source and publish data:

Journal of Medicinal Chemistry p. 52 - 60 (1990)

Update date:2022-09-26

Topics:

Authors:

Beck, G.

Kesseler, K.

Baader, E.

Bartmann, W.

Bergmann, A.

et al. et al.

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Article abstract of DOI:10.1021/jm00163a010

Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids 2-4 have been synthesized.Extensive exploration of structure-activity relationships led to several compounds exceeding the inhibitory activity of mevinolin (1b)

Full text of DOI:10.1021/jm00163a010

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