Non-Proteinogenic Amino Acid Synthesis. The β-Anion Derived from Aspartic Acid, and its Application to α-Amino Acid Synthesis.

Article abstract of DOI:10.1016/S0040-4020(01)85140-1

Treatment of α-t-butyl β-methyl N-Z-(S)-aspartate (2) with lithium amide bases generates the corresponding β-ester enolate, which can be alkylated with suitable electrophiles.The application of this strategy for synthesis of optically active amino acids h