A microbially-based approach for the synthesis of chiral secondary alcohols bearing the difluoromethyl or chlorodifluoromethyl group

DOI: 10.1016/S0022-1139(00)81174-4

Source and publish data:

Journal of Fluorine Chemistry p. 271 - 284 (1992)

Update date:2022-07-30

Topics:

Authors:

Kitazume, Tomoya

Asai, Masatomo

Tsukamoto, Takashi

Yamazaki, Takashi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0022-1139(00)81174-4

A synthetic approach to both enantiomers of the secondary alcohols , involving the stereoselective hydrolysis of ester derivatives, is described.The absolute configurations of these difluoromethylated or chlorodifluoromethylated molecules were determined.

Full text of DOI:10.1016/S0022-1139(00)81174-4

Products guided by the article

Product name:(S)-1-Chloro-1,1-difluoro-4-phenyl-butan-2-ol

Cas No:123986-90-3

R&D Labs maybe for 123986-90-3

Shijiazhuang Haotian Chemical Co., Ltd.

Contact:86-311-85044374

Address:293 Donggang Road
SEA BRGIHT INDUSTRY CO.,LIMITED

Contact:0086 755 8622 3990

Address:Rm 17B3,GuangCaiXinTianDi Bldg,GuiMiao Rd,NanShan District,Shenzhen,China
Hangzhou Haichem Co.,Ltd.

Contact:+86-571-86025531 / 86024803

Address:1218-24 Guangyin Mansion,42 Fengqi East Road
Wuhan Shangrisyn chemicals Technology Co.,Ltd(expird)

Contact:+86-027-84466317 __ +86-15387123698

Address:wuhan - china
Melone Pharmaceutical Co., ltd

Contact:+86-411 82593920, 82593631

Address:No 232, JInma Roda, Development Zone, Dalian, China

Relevant to this article

Tuning mechanism in helical columnar thiophene host system with 2-thienylacetic acid by using (1R, 2S)-2-amino-1, 2-diphenylethanol

Doi:10.1016/j.tet.2010.05.098
(2010)
Helical Oligourea Foldamers as Powerful Hydrogen Bonding Catalysts for Enantioselective C-C Bond-Forming Reactions

Doi:10.1021/jacs.7b05802
(2017)
Synthesis and anti-HIV activity of 2′-deoxy-2′-fluoro-4′-C-ethynyl nucleoside analogs

Doi:10.1016/j.bmcl.2010.05.090
(2010)
Polymer-supported pentaethylene glycol as a facile heterogeneous catalyst for nucleophilic fluorination

Doi:10.1021/ol101485n
(2010)
Doi:10.1016/S0277-5387(00)86787-X
(1990)
P-trifluoromethyldiazirinyl-etomidate: A potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels

Doi:10.1021/jm100498u
(2010)

Article Doi