Structure-Activity Relationships of N2-Substituted Guanines as Inhibitors of HSV1 and HSV2 Thymidine Kinases

DOI: 10.1021/jm00163a033

Source and publish data:

Journal of Medicinal Chemistry p. 203 - 206 (1990)

Update date:2022-09-26

Topics:

Authors:

Hildebrand, Catherine

Sandoli, Daniele

Focher, Federico

Gambino, Joseph

Ciarrocchi, Giovanni

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00163a033

A series of N²-phenylguanines was synthesized and tested for inhibition of the thymidine kinases encoded by Herpes simplex viruses type 1 and type 2.Compounds with hydrophobic, electron-attracting groups in the meta position of the phenyl ring

Full text of DOI:10.1021/jm00163a033

Products guided by the article

Product name:N²-n-hexyl-2'-deoxyguanosine

Cas No:123994-86-5

R&D Labs maybe for 123994-86-5

Shanghai agrotree chemical co.,ltd.

Contact:+86-21-50117563

Address:Room 8A,liangfeng building,No.8 dongfang RD.pudong,shanghai,China
JIANGXI ZHANGFENG CHEMICAL CO., LTD.

Contact:+86-0799-3413066

Address:Xiyuan village, Xiabu Town, Xiangdong District
Tangshan Moneide Trading Co., Ltd.

Contact:+86-315-8309571

Address:2-7-420 Jidong Building Materials Commercial Center, Tangshan, Hebei, 064000 China
Guangzhou Reachin Chemical Co., Ltd

Contact:+86-20-37087379 ext.604

Address:A122C-1, Tianyuan Plaza, 401 Tianyuan Rd., Tianhe, Guangzhou, China
Zibo Xiaoguang Chemical Material Co., Ltd

Contact:15954099116

Address:Boshan Development Zone

Relevant to this article

Synthesis of N-aryl trifluoromethylarylketoimines by palladium-catalyzed Suzuki coupling reaction of N-aryltrifluoroacetimidoyl chlorides with aryl boronic acids

Doi:10.1016/j.jfluchem.2010.04.011
(2010)
Isoprene-mediated lithiation of 1-alkylimidazoles: Chiral induction of the alkyl substituent

Doi:10.2174/157017810791514850
(2010)
Enhancing the solubility for hypervalent ortho-sulfonyl iodine compounds

Doi:10.1016/j.tet.2010.04.087
(2010)
Dithienophosphole-capped π-conjugated oligomers

Doi:10.1039/c0nj00026d
(2010)
Fluorescence turn-on sensing of lectins with mannose-substituted tetraphenylethenes based on aggregation-induced emission

Doi:10.1002/asia.200900430
(2010)
Synthesis and properties of (E)-4-[alkyl(aryl)iminomethyl]-2- methoxy(ethoxy)phenyl adamantane-1-carboxylates

Doi:10.1134/S107042801004010X
(2010)

Article Doi