Synthesis and Biological Evaluation of New Antimuscarinic Compounds with Amidine Basic Centers. A Useful Bioisosteric Replacement of Classical Cationic Heads

DOI: 10.1021/jm00170a010

Source and publish data:

Journal of Medicinal Chemistry p. 2108 - 2113 (1990)

Update date:2022-09-26

Topics:

Authors:

Cereda, Enzo

Ezhaya, Antoine

Quintero, Myrna Gil

Bellora, Elio

Dubini, Enrica

et al. et al.

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Article abstract of DOI:10.1021/jm00170a010

Amidines (guanidine, formamidine, and acetamidine) were introduced as substitutes for the cationic heads present in atropine, scopolamine, and corresponding quaternary derivatives.Amidine systems are intermediate in structure between tertiary amines and q

Full text of DOI:10.1021/jm00170a010

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