Regioselectivity of acid-catalyzed cyclization of 1-(3,4-dialkylaryl)-3- chloropropan-1-ones to indanones. Comparison of experimental data and results of computer simulation

Article abstract of DOI:10.1007/s11172-009-0117-0

The acid-catalyzed cyclization of 1-(3,4-dialkylaryl)-3-chloropropan-1-ones to dialkyl-indanones via the intermediate formation of (3,4-dialkylaryl) propenones was studied. This reaction affords isomeric products: 5,6-dialkylindan-1-ones and 4,5-dialkylin