Conformationally Constrained Renin Inhibitory Peptides: Cyclic (3-1)-1-(Carboxymethyl)-L-prolyl-L-phenylalanyl-L-histidinamide as a Conformational Restriction at the P2-P4 Tripeptide Portion of the Angiotensinogen Template

Article abstract of DOI:10.1021/jm00108a006

Interest in conformationally constrained peptides as potential inhibitors of renin led us to examine an N-terminal cycle of linear renin inhibitory peptides.A cyclic structure was prepared by joining the N-terminal proline at the P4 site to the imidazole