Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites

Article abstract of DOI:10.1021/jm00164a058

Renin inhibitors having 13 different isosteres connecting the P₃ and P₂ positions have been prepared. Synthetic routes and in vitro activity exhibited by these compounds are discussed. The two most potent compounds, 47 and 48, contai