Journal of Medicinal Chemistry p. 838 - 845 (1990)
Update date:2022-08-03
Topics:
Kaltenbronn
Hudspeth
Lunney
Michniewicz
Nicolaides
Repine
Roark
Stier
Tinney
Woo
Essenburg
Renin inhibitors having 13 different isosteres connecting the P3 and P2 positions have been prepared. Synthetic routes and in vitro activity exhibited by these compounds are discussed. The two most potent compounds, 47 and 48, contai
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