Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites

DOI: 10.1021/jm00164a058

Source and publish data:

Journal of Medicinal Chemistry p. 838 - 845 (1990)

Update date:2022-08-03

Topics:

Authors:

Kaltenbronn

Hudspeth

Lunney Lunney

Michniewicz

Nicolaides

Repine Repine

Roark Roark

Stier Stier

Tinney Tinney

Woo Woo

Essenburg

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Article abstract of DOI:10.1021/jm00164a058

Renin inhibitors having 13 different isosteres connecting the P₃ and P₂ positions have been prepared. Synthetic routes and in vitro activity exhibited by these compounds are discussed. The two most potent compounds, 47 and 48, contai

Full text of DOI:10.1021/jm00164a058

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