Highly selective κ-opioid analgesics. 3. Synthesis and structure-activity relationships of novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted-cyclohexyl]arylacetamide derivatives

Article abstract of DOI:10.1021/jm00163a047

This paper describes the chemical synthesis, μ/κ opioid receptor selectivity and analgesic activity of 14 novel N-[2-(1-pyrrolidinyl)-4- or -5-substituted-cyclohexyl]arylacetamide derivatives. The prototype κ-selective agonist, PD117302 (trans-N-methyl-N-