Tetrahedron p. 3627 - 3632 (1988)
Update date:2022-08-05
Topics:
Langendoen, Albert
Koomen, Gerrit-Jan
Pandit, Upendra K.
Reactions of 6-methylellipticine (3a) with the aim of preparing various functionalized derivatives have been studied.A base-(LDA) mediated reaction of 3a with formaldehyde results in a C(11)-hydroxyethyl derivative (3d), which has been coupled with ribose-, glucose- and galactose derivatives to give, after deprotection, novel ellipticine glycosides 3e-g.The sequene of reactions constitute a new strategy for the synthesis of a wide range of ellipticine derivatives with improved solubility characteristics.
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